Large Scale Initiative Action

REGATE: REgulation of the GonAdoTropE axis

[HHG axis]

Project overview

Overall objectives

REGATE lies at the border between Applied Mathematics, Control Theory and Computer Science on one hand, Physiology, Endocrinology and Cellular Biology on the other hand. It is interested in the multi-level and multi-scale modelling, simulation and control of the gonadotrope axis (also called hypothalamo-hypophyso-gonadal axis). The project articulates on the coupling between different mathematical (mainly: conservation laws and dynamical systems) and computing (mainly: temporal logic and model checking) formalisms with biological knowledge and data.
REGATE emanates from the former working group REGLO (REGuLation of Ovulation), which first benefited from an ACI (Concerted Incentive Action) RNTS (National Network on Health Technologies) in 2002-2003 and then from an INRIA Research Cooperative Action in 2005-2006. A complementary systems biology approach was initiated at the beginning of 2007 in the framework of the INRA AgroBI program. REGATE has been launched in 2009 for a 4 year timespan.

Research themes


Units Teams Participants
UMR Physiology of Reproduction and Behaviour
INRA-CNRS-Université François Rabelais-Haras Nationaux
Integrative Biology of the Ovary
Biology and BioInformatics of Signalling systems
Integrative Neurobiology of Reproduction
S Fabre, D Monniaux, C Rico
P Crépieux, D Heitzler, E Reiter, A Poupon
P. Chemineau, B. Malpaux
INRIA Paris-Rocquencourt Signals and Systems in Physiology and Engineering
Associate participants

Constraint programming
F Clément, M Desroches, A. Granados, M Krupa, C Médigue, P Shang
P Michel (Centrale Lyon), A Vidal (Evry Val d'Essone)
F Fages, A Rizk
Jacques-Louis Lions Laboratory B Aymard, F Coquel, JM Coron, JP Françoise, M Postel


Florida State University Department of Mathematics R Bertram, P Fletcher, J Tabak
Antoine Béclère HospitalDepartment of Obstetrics, Gynaecology and Reproductive MedicineR Fanchin, M Grynberg
Theoretical Chronobiology UnitG Dupont, A Goldbeter



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updated by Frédérique Clément 04/28/14