E-cadherin-beta-catenin

Tumour interface: beta-catenin distribution beta catenin is known to be an important protein involved in cancer invasion. Malignant tumours show high concentration of soluble beta-catenin at the outer rim (orange) than in the central core (red).

beta catenin is known to be an important protein involved in cancer invasion. Malignant tumours show high concentration of soluble beta-catenin at the outer rim (orange) than in the central core (red).

E-cadherin-beta-catenin interactions play a key role in cancer invasion and epithelial mesenchymal transition. Motivated by its influence in cell-cell adhesion, the dynamics of this pathway depend strongly on the biophysical properties of the cell.

To approach this problem, a mathematical hybrid multi-scale forced-based model, provides a good frame to include all the main variables.

Publications:

Modelling the influence of E-cadherin-beta-catenin pathway in cancer cell invasion: A multi-scale approach.

Ignacio Ramis-Conde, Dirk Drasdo, Alexander A.R. Anderson, Mark A.J. Chaplain. Biophysical journal.

Preprint

Invasion 1

Invasion 2

Invasion 3